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DEPARTMENT OF VETERINARY

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Veterinary Physiology Ⅱ

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vetmed_eng_JW_MS_K2WT001_S
    • Name : Soo Hyun Park
    • Address : Colleage of Veterinary Medicine, Chonnam National University. 300 Yonbongdong, Buk-gu, Gwangju,# 500-757, Republic of Korea
    • Tel : +82-62-530-2832
    • Fax : +82-62-530-2809
    • E-MAIL : parksh@chonnam.ac.kr

We educate and research physiological functions of animals as it relates ti mechanisms from molecular to body levels. We aim at the establishment of basic conception of normal physiology to understand the study of the abnormal function of the body. Thus,veterinary physiology is introduced first in the veterinary curriculum..

Main Research Interests

  • 1. Molecular mechanism of functional differentiation of embryonic stem cells
  • 2. Signal cascades involved in hormonal regulation of renal proximal tubule cells
  • 3. Pathogenesis of nephropathy under abnormal conditions
  • 4. Study of the regulation of growth factors in vivo and in vitro

Recent Publication Lists

  • 1. Lee MY, Lee SH, Lee SG, Park SH, Lee CY, Kim KH, Hwang SH, Lim SY, Ahn YK, Han HJ.Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography. J Vet Sci. 2007;8(1):7-14.
  • 2. Kim DI, Lim SK, Park MJ, Han HJ, Kim GY, Park SH. The involvement of phosphatidylinositol 3-kinase /Akt signaling in high glucose-induced downregulation of GLUT-1 expression in ARPE cells.Life Sci. 2007; 80(7): 626-32.
  • 3. Han HJ, Kang CW, Park SH. Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro.Clin Exp Pharmacol Physiol. 2006;33(12):1172-9.
  • 4.Lee MY, Lee SH, Kim YH, Heo JS, Park SH, Lee JH, Han HJ. Effect of EGF on [3H]-thymidine incorporation and cell cycle regulatory proteins in primary cultured chicken hepatocytes: Involvement of Ca2+/PKC and MAPKs.J Cell Biochem. 2006;99(6):1677-87.
  • 5. Lee MY, Park SH, Lee YJ, Heo JS, Lee JH, Han HJ. EGF-induced inhibition of glucose transport is mediated by PKC and MAPK signal pathways in primary cultured chicken hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2006;291(4):G744-50.
  • 6. Han HJ, Park SH. Alteration of the gene and protein levels of insulin-like growth factors in streptozotocin-induced diabetic male rats. J Vet Med Sci. 2006;68(5):413-9.
  • 7. Park SH, Min TS. Caffeic acid phenethyl ester ameliorates changes in IGFs secretion and gene expression in streptozotocin-induced diabetic rats. Life Sci. 2006;78(15):1741-7.
  • 8. Kim JC, Shin JY, Shin DH, Kim SH, Park SH, Park RD, Park SC, Kim YB, Shin YC. Synergistic antiinflammatory effects of pinitol and glucosamine in rats. Phytother Res. 2005;19(12):1048-51.
  • 9. Kim JC, Shin DH, Park SH, Park SC, Kim YB, Kim HC, Cha SW, Cho KH, Kang BH, Chung MK. 4-Week repeated intravenous dose toxicity study of a new camptothecin anticancer agent CKD-602 in dogs. Food Chem Toxicol. 2005; 43(5):699-706.
  • 10. Lee YJ, Park SH, Han HJ. ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1268-76.
  • 11. Lee YJ, Park SH, Jeung TO, Kim KW, Lee JH, Han HJ. Effect of adenosine triphosphate on phosphate uptake in renal proximal tubule cells: involvement of PKC and p38 MAPK. J Cell Physiol. 2005;205(1):68-76.
  • 12. Park SH, Heo JS, Kang CW. Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats. Clin Exp Pharmacol Physiol. 2004;31(1-2):22-8.
  • 13. Han HJ, Park JY, Lee YJ, Park SH. Effect of epidermal growth factor on phosphate uptake in renal proximal tubule cells: involvement of PKC, MAPK, and cPLA2. Kidney Blood Press Res. 2003;26(5-6):315-24.
  • 14. Han HJ, Park SH, Lee YJ. Signaling cascade of ANG II-induced inhibition of alpha-MG uptake in renal proximal tubule cells. Am J Physiol Renal Physiol. 2004 286(4):F634-42.
  • 15. Han HJ, Park SH, Lee YJ, Lee JC, Lee JH. Effect of ATP on Ca2+ uptake in the presence of high glucose in renal proximal tubule cells. Clin Exp Pharmacol Physiol. 2003; 30(9):694-701.
  • 16. Han HJ, Park SH, Lee YJ. Epidermal growth factor regulates Ca2+ uptake in primary cultured renal proximal tubule cells: involvement of cAMP, PKC and cPLA2. Kidney Blood Press Res. 2003;26(3):155-64.
  • 17. Han HJ, Yoon BC, Oh YJ, Park SH, Lee JH, Mar WC. The water-soluble fraction (10 kD) of bee venom (Apis mellifera) produces inhibitory effect on apical transporters in renal proximal tubule cells.Kidney Blood Press Res. 2002;25(6):375-83.
  • 18. Han HJ, Yoon BC, Lee SH, Park SH, Park JY, Oh YJ, Lee YJ. Ginsenosides inhibit EGF-induced proliferation of renal proximal tubule cells via decrease of c-fos and c-jun gene expression in vitro.Planta Med. 2002;68(11):971-4.
  • 19. Han HJ, Yoon BC, Park SH, Park JY, Oh YJ, Lee YJ, Park KM. Ginsenosides protect apical transporters of cultured proximal tubule cells from dysfunctions induced by h(2)o(2). Kidney Blood Press Res. 2002;25(5):308-14.
  • 20. Han HJ, Park SH,Park KM, Yoon BC, Kim TS, Lee JH. Effect of caffeic acid on apical transporters' dysfunction of renal proximal tubule cells under oxidative stress in vitro. Planta Med. 2002 ;68(6):483-6.
  • 21. Han HJ, Park SH, Lee JH, Yoon BC, Park KM, Mar WC, Lee HJ, Kang SK. Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells. Clin Exp Pharmacol Physiol. 2002 29(7):564-8.
  • 22. Han HJ, Park SH, Park HJ, Park KM, Kang JW, Lee JH, Lee BC, Hwang WS. Effect of various oestrogens on cell injury and alteration of apical transporters induced by tert-butyl hydroperoxide in renal proximal tubule cells. Clin Exp Pharmacol Physiol. 2002;29(1-2):60-7.
  • 23. Park SH, Woo CH, Kim JH, Lee JH, Yang IS, Park KM, Han HJ. High glucose down-regulates angiotensin II binding via the PKC-MAPK-cPLA2 signal ascade in renal proximal tubule cells. Kidney Int. 2002;61(3):913-25.
  • 24. Park SH, Han HJ. The mechanism of angiotensin II binding downregulation by high glucose in primary renal proximal tubule cells. Am J Physiol Renal Physiol. 2002 :282(2):F228-37.
  • 25. Han HJ, Park SH, Park HJ, Lee JH, Lee BC, Hwang WS. Effects of sex hormones on Na+/glucose cotransporter of renal proximal tubular cells following oxidant injury. Kidney Blood Press Res. 2001;24(3):159-65.
  • 26. Park SH, Shin SS, Han HJ. High glucose levels alter angiotensin II-induced Ca2+ uptake via PKC and cAMP pathways in renal proximal tubular cells. Kidney Blood Press Res. 2001;24(2):84-91.
  • 27. Park SH, Choi HJ, Lee JH, Woo CH, Kim JH, Han HJ. High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta1. Kidney Int. 2001 59(5):1695-1705.
  • 28. Park SH, Taub M, Han HJ. Regulation of phosphate uptake in primary cultured rabbit renal proximal tubule cells by glucocorticoids: Evidence for nongenomic as well as genomic mechanisms. Endocrinology.2001: 142: 710-720.
  • 28. Park SH, Choi HJ, Yang IS, Lee JH, Han HJ. High glucose stimulates Ca2+ uptake via cAMP and PLC/PKC pathways in primary cultured renal proximal tubule cells. Kidney &Blood Press Res. 2001: 24: 10-17.
  • 30. Han HJ, Lee JH, Park SH, Choi HJ, Yang IS, Mar WC, Kang SK, Lee HJ. Effect of bee venom and its melittin on apical transporters of renal proximal tubule cells. Kidney Blood Press Res. 2000;23(6):393-399.
  • 31. Han HJ, Choi HJ, Park SH. High glucose-induced inhibition of alpha-methyl-D-glucopyranoside uptake is mediated by protein kinase C-dependent activation of arachidonic acid release in primary cultured rabbit renal proximal tubule cells. J Cell Physiol. 2000;183(3):355-363.
  • 32. Han HJ, Choi HJ, Park SH. High glucose inhibits glucose uptake in renal proximal tubule cells by oxidative stress and protein kinase C. Kidney Int. 2000;57(3):918-926.
  • 33. Ho Jae Han, Soo Hyun Park, Hyun Ju Kho, Mary Taub.Mechanism of regulation of Na+ transport by angiotensin II in primary renal cells. Kidney International. 2000: 57(6):2457-67
  • 34. Ho Jae Han, Hyun Ju Choi, Soo Hyun Park. High glucose-induced inhibition of -MG uptake is mediated by protein kinase C-dependent activation of arachidonic acid release in primary cultured rabbit renal proximal tubule cells. J Cell Physiol. 2000 183(3):355-63.
  • 35. Ho Jae Han, Hyun Ju Choi, Soo Hyun Park. High glucose inhibits glucose uptake in renal proximal tubule cells: Involvement of oxidative stress and protein kinase C. Kidney International. 2000; 57(3):918-26.
  • 36. Ho Jae Han, Yeune Hee Lee, Soo Hyun Park. Estradiol-17B-BSA stimulates Ca2+ uptake through nongenomic pathways in primary rabbit kidney proximal tubule cells: Involvement of cAMP and PKC. J Cell Physiol. 2000 ;183(1):37-44.
  • 37. Ho Jae Han, Hyun Ju Koh, Soo Hyun Park. A potential signaling pathway in stimulation of Na+ uptake induced by ANG II in primary cultured rabbit renal proximal tubule cells. J Vet Med Sci 1999: 61(2) : 135-141
  • 38. Ho Jae Han, Dae Hoon Kim, Soo Hyun Park, Young Soon Lee, Jang Hern Lee, Il Suk Yang (1999) Regulatory mechanism of polarized membrane transport by glucocorticoid in renal proximal tubule cells: Involvement of [Ca2+]i . J Vet Med Sci 61(11); 1197-1202
  • 39. Ho Jae Han, Dae Hoon Kim, Soo Hyun Park. Regulatory mechanism of Na/Pi cotransport by glucocorticoid in renal proximal tubule cells: Involvement of cAMP and PKC. Kidney &Blood Pressure Research 1999: 23 : 1-9
  • 40. Ho Jae Han, Soo Hyun Park, Jae Cheon Lee, Hwanghee Blasie Lee, Haeng Soon Park. Leukotrien D4 inhibits Na uptake through cAMP and PLCpathway in the primary cultured renal proximal tubular cells. Kidney &Blood Pressure Research. 1999: 22(3) : 106-113
  • 41.Ho Jae Han, Soo Hyun Park, Hyun Ju Kho, Seung Yeol Nah, Dong Ho Shin, Han Sun Choi. Ginsenoside-protopanaxatriol inhibits glucose uptake in primary cultured rabbit renal proximal tubular cells by arachidonic acid release. Kidney &Blood Pressure Research. 1999: 22(3): 114-120