• HOME
  • KOR
  • SITEMAP
  • CNU Univ.

DEPARTMENT OF VETERINARY

  • HOME
  • > Laboratories
  • > Veterinary Biochemistry

Veterinary Biochemistry

/WEB-INF/jsp/k2web/com/cop/site/layout.jsp
vetmed_eng_JW_MS_K2WT001_S
    • Name : Tae Ho Ahn
    • Address : Colleage of Veterinary Medicine, Chonnam National University. 300 Yonbongdong, Buk-gu, Gwangju,# 500-757, Republic of Korea
    • Tel : +82-62-530-2823
    • Fax : +82-62-530-2809
    • E-MAIL : thahn@chonnam.ac.kr

Veterinary biochemistry is a field of life sciences that studies various life phenomena in animals with physical and chemical methods. So, it forms the foundation of all other veterinary medicine.

This subject studies molecular structure, function and metabolism of macromolecules in animals and helps to understand other veterinary science at the molecular level. Furthermore, veterinary biochemistry provides the theoretical basis to be applied to veterinary preventive medicine and other clinical fields.

Main Research Interests

  • 1. Development of early diagnostic methods for liver diseases using cytochrome P450 family as a biological marker
  • 2. Establishment of a database for cytochrome P450 proteomes in disease-induced animal models
  • 3. Development of cytochrome P450 protein micro-arrays using cytomimetic phospholipid monolayers.
  • 4. Studies interaction between cytochrome P450 family and molecular chaperones
  • 5. Development of efficient production methods of recombinant proteins using the regulation of protein translocation machinaries in Escherich

Recent Publication Lists

  • 1. BC Ahn, T. and Kim, H.(1994) SecA of Escherichia coli Traverses Lipid Bilayer of Phospholipid Vesicles. Biochem. Biophys. Res. Comm. 203, 326-330
  • 2. Ahn, T. and Kim, H.(1996) Differential Effect of Precursor Ribose Binding Protein of Escherichia coliand Its Signal Peptide on the SecA Penetration of Lipid Bilayer. J. Biol. Chem. 271, 12372-12379
  • 3. Yun, C-H., Song, M., Ahn, T., and Kim, H.(1996) Conformational Change of Cytochrome P450 1A2 Induce by Sodium Chloride. J. Biol. Chem. 271, 31312-31316
  • 4. Ahn, T. and Kim, H.(1998) Effects of Nonlamellar-Prone Lipids on the ATPase Activity of SecA bound to Model Membranes. J. Biol. Chem. 273, 21692-21698
  • 5. Ahn, T. and Yun, C-H.(1998) Phase Separation in Phosphatidylcholine/Anionic Phospholipid Membranes in Liquid-Crystalline State Revealed with Fluorescent Probes. J. Biochem. (Tokyo) 124, 622-627
  • 6. Yun, C-H., Ahn, T., and Guengerich, F. P. (1998) Conformational Change and Activation of Cytochrome P450 2B1 Induced by Salt and Phospholipid. Arch. Biochem. Biophys. 356, 229-238
  • 7. Ahn, T., Guengerich, F. P., and Yun, C-H. (1998) Membrane Insertion of Cytochrome P450 1A2 Promoted by Anionic Phospholipids. Biochemistriy 37, 12860-12866
  • 8. Ahn, T. and Yun, C-H. (1999) Phase Properties of Liquid-Crystalline Phosphatidylcholine/Phosphatidyethanolamine Bilayers Revealed by Fluorescent Probes. Arch. Biochem. Biophys. 369, 288-294
  • 9. Yun, C-H., Ahn, T., Guengerich, F. P., Yamazaki, H., and Shimada, T. (1999) Phospholipase D Activity of Cytochromes P450 in Human Liver Endoplasmic Reticulum. Arch. Biochem. Biophys. 367, 81-88
  • 10. Park, Y., Cho, Y., Ahn, T., and Park, C. (1999) Molecular interactions in ribose transport: the binding protein module symmetrically associates with the homodimeric membrane transporter. EMBO J. 18, 4149-4156
  • 11. Ahn, T., Kim, J.S., Lee, B.C., and Yun, C-H. (1999) Effects of lipids on the interaction of SecA with model membranes. Arch. Biochem. Biophys. 395, 14-20
  • 12. Ahn, T., Oh, D-B., Lee, B-C., and Yun, C-H.(2000) Importance of Phosphatidylethanolamine for the Interaction of Apocytochrome c with Model Membranes containing Phosphatidylserine. Biochemistry 39, 10147-10153
  • 13. Yoo, S. H., Kang, M. K., Kwon, H. S., Lee, J. S., So, S. H., Ahn, T., and Jeon, C. J. (2000) Inositol 1,4,5-trisphosphate receptor and chromogranins A and B in secretory granules. Co-localization and functional coupling Adv Exp Med Biol 482, 83-94
  • 14. Kim, J-S., Ahn, T., Ko, J., Park, C., and Kim, H. (2001) Effect of divalent cations on the ATPase activity of Escherichia coli SecA. FEBS lett. 493, 12-16
  • 15. Ahn, T., Yim, S-K., Choi, H-I., and Yun, C-H.(2001) Polyacrylamide gel electrophoresis without a stacking gel: use of amino acids as electrolytes. Anal. Biochem. 491, 300-303
  • 16. Yim, S-K., Ahn, T., Kim, J-S., and Yun, C-H. (2002) Polyacrylamide Gel Electrophoresis without a Stacking Gel: Application for Separation of Peptides. Anal. Biochem. 305, 277-279
  • 17. Ahn, T., Kim, J-S., Choi, H-I., and Yun, C-H. (2002) Development of Peptide Substrates for Trypsin Based on the Monomer/Excimer Fluorescence of Pyrene. Anal. Biochem. 306, 247-251
  • 18. Ahn, T., Oh, D-B., Kim, H., and Park, C. (2002) The phase property of membrane phospholipids is affected by the functionality of signal peptides from the Escherichia coli ribose-binding protein. J. Biol. Chem. 277, 26157-26162
  • 19. Kim, J-S., Ahn, T., Yim, S-K., and Yun, C-H. (2002) Differential Effect of Copper(II) on the Cytochrome P450 Enzymes and NADPH-Cytochrome P450 reductase. Biochemistry 41, 9438-9447
  • 20. AC Kim, K-H., Ahn, T., and Yun, C-H. (2003) Membrane Properties Induced by Anionic Phospholipids and Phosphatidylethanolamine Are Critical for the Membrane Binding and Catalytic Activity of Human Cytochrome P450 3A4. Biochemistry 42, 15377-15387 (corresponding author)
  • 21. Kim, J.C., Shin, D.H., Ahn, T., Kang, S.S., Song, S.W., Han, J., Kim, C.Y., Ha, C.S., Chung, M.K. (2003) 26-Week repeated oral dose toxicity study of the new quinolone antibacterial DW-116 in Sprague-Dawley rats. Food Chem. Toxicol. 41, 637-645
  • 22. Kim, J.C., Kim, S.H., Shin, D.H., Ahn, T., Chung, M.K (2003) Developmental toxicity evaluation of the new fluoroquinolone antibacterial DW-116 in rats. Teratog. Carcinog. Mutagen Suppl 1, 123-136
  • 23. Kim, JC., Kim, SH., Shin, DH., Ahn, T., Chung, MK (2004) Effects of prenatal exposure to the environmental pollutant 2-bromopropane on embryo-fetal development in rats. Toxicology 196, 77-86
  • 24. Ahn, T. and Yun, C-H. (2004) High-level Expression of Human Cytochrome P450 3A2 by Co-expression with Human Molecular Chaperone HDJ-1 (Hsp40). Arch. Pharm. Res. 27, 319-323
  • 25. Ahn, T. Yang, S., and Yun, C-H. (2004) High-level Expression of Human Cytochrome P450 1A2 by Co-expression with Human Molecular Chaperone HDJ-1 (Hsp40). Protein Expr. Purif. 36, 48-52
  • 26. Ahn, T. Yang, S., and Yun, C-H. (2004) Enhanced Expression of Human Cytochrome P450 1A2 by Co-expression with Human Molecular Chaperone Hsp70. Toxicol. Lett. (in press)
  • 27. Ahn, T. and Yun, C-H. (2004) Trehalose Increases Chemical-induced Transformation Efficiency of Escherichia coli. Anal. Biochem. (in press)
  • 28. Ahn, T. and Kang, S.S. and Yun, C-H. Effect of Trehalose on the Long-term Storage of Competent Cells in Chemical-induced Transformation of Escherichia coli. Biotechniques (in press)
  • 29. Ahn, T. and Park, C. (2004) Signal Peptide and Adenosine Nucleotides Act Differently on the Dimerization and Membrane Binding of Soluble SecA. Biochem. J. (submitted)