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- Name : Ho Jae Han
- Address : Colleage of Veterinary Medicine, Chonnam National University. 300 Yonbongdong, Buk-gu, Gwangju,# 500-757, Republic of Korea
- Tel : +82-62-530-2837
- Fax : +82-62-530-2841
- E-MAIL : shokim@chonnam.ac.kr
Physiology is a branch of biology that deals with function and coordinated activities of cells, tissues, and organs. The study of physiology offers you not only the satisfaction of knowing something about the workings of the body, but it also may provide you a deep, perhaps even profound, understanding of it. Your study of physiology will broaden your scientific interests and will widen the scope of your outlook.
Main Research Interests
- 1. Hormonal control of functional differentiation of embryonic stem cells
- 2. Regulatory mechanisms of cell membrane functions by hormones
- 3. Signal cascades involved in hormonal regulation of renal proximal tubule cells
- 4. Characterization of useful genes using molecular biological techniques
Recent Publication Lists
- 1. Seung Pil Yun, Min Yong Lee, Jung Min Ryu, Ho Jae Han (2009) Interaction between PGE2 and EGF receptor through MAPKs in mouse embryonic stem cell proliferation. Cell Mol Life Sci (Mar 3, aceepted)
- 2. Jung Min Ryu, Dong Hyun Kim, Min Young Lee, Sang Hun Lee, Jae Hong Park, Seung Pil Yun, Min Woo Jang, Seong Hwan Kim, Gyu-Jin Rho, Ho Jae Han.(2009) Imaging evaluation of the liver using multi-detector row computed tomography in micropigs as potential living liver donors. J Vet Sci (Feb 16, accepted)
- 3. Jang-Hern Lee, Seo-Yeon Yoon, Dae-Hyun Roh, Hyoung-Sig Seo, Suk-Yun Kang, Ho-Jae Han, Alvin Beitz. (2009) Intrathecal injection of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS) produces mechanical allodynia in mice: Involvement of spinal sigma-1 and GABA receptors. British Journal of Pharmacology (Dec 23, accepted)
- 4. Min Young Lee, Sang Hun Lee, Jae Hong Park, Ho Jae Han (2009) Interaction of galectin-1 with caveolae induces mouse ES cell proliferation through the Src, ERas, Akt, and mTOR signaling pathway. Cell Mol Life Sci (Epub ahead of print)
- 5. Yoon SY, Roh DH, Kwon YB, Kim HW, Seo HS, Han HJ, Lee HJ, Beitz AJ, Lee JH. (2009). Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal cloinidine in the rodent formalin test and in a neuropathic pain model. J Pain 10(3):253-63
- 6. Yu Jin Lee, Han Na Suh, Ho Jae Han. (2009) Effect of BSA-induced ER stress on SGLTs protein expression levels and a-MG uptake in renal proximal tubule cells. Am J Physiol-Renal Physiol (Epub ahead of print)
- 7. Mi Ok Kim, Min Hee Kim, Sang Hun Lee, Han Na Suh, Yu Jin Lee, Min Young Lee, Ho Jae Han (2009) 5'-N-Ethylcarboxamide induced IL-6 expression via MAPKs and NF-kB activation through Akt, Ca2+/PKC, cAMP signaling pathways in mouse embryonic stem cells. J Cell Physiol (Epub ahead of print)
- 8. Min Hee Kim, Mi Ok Kim, Yun Hee Kim, Jin Sang Kim, Ho Jae Han(2009) Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. J Physiol Biochem 23:53-64
- 9. A Young Jung, Min Yong Lee, Sang Hun Lee, Jae Hong Park, Ho Jae Han. (2009) PPARδ agonist-mediated ROS stimulates mouse embryonic stem cell proliferation through cooperation of p38 MAPK and Wnt/β-catenin. Cell Cycle 8:611-9
- 10. Sang Hun Lee, Sun Im Na, Jung Sun Heo, Min Hee Kim, Yun Hee Kim, Min Young Lee, Seong Hong Kim, Yun Jung Lee, Ho Jae Han.(2009) Arachidonic acid release by H2O2 mediated proliferation of mouse embryonic stem cells : Involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation. J Cell Biochem 106:787-97
- 11. Seung Phil Yun, Jung Min Ryu, Min Young Lee, Chang Hun Song, Ho Jae Han (2009) Role of HIF-1α and VEGF in human mesenchymal stem cell proliferation by estradiol-17β : Involvement of the PKC, PI3K/Akt, and MAPKs. Am J Physiol-Cell Physiol 296:C317-26
- 12. Jae Hong Park, Min Young Lee, Ho Jae Han.(2009) A potential role for caveolin-1 in estradiol-17β-induced proliferation of mouse embryonic stem cells: Involvement of Src, PI3K/Akt, and MAPKs pathway. Int J Biochem Cell Biol 41:659-65
- 13. Han Na Suh, Yu Jin Lee, Ho Jae Han (2009) Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes. J Cell Physiol 218(3):643-52
- 14. Jung Min Ryu, Seung Phil Yun, Min Young Lee, Ho Jae Han (2009) Zinc chloride stimulates DNA synthesis of mouse embryonic stem cells: Involvement of PI3K/Akt, MAPKs, and mTOR. J Cell Physiol 218(3):558-67
- 15. Han Na Suh, Sang Hun Lee, Min Young Lee, Yu Jin Lee, Jang Hern Lee, Ho Jae Han. (2008) Role of interleukin-6 in the control of DNA synthesis of hepatocytes: Involvement of PKC, p44/42 MAPKs, and PPARs. Cell Physiol Biochem 22(5-6):673-84
- 16. Han Na Suh, Huang Thi Huong, Chang Hun Song, Jang Hern Lee, Ho Jae Han. (2008) Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPARs pathways through GPR40 in primary cultured chicken hepatocytes. Am J Physiol-Cell Physiol 295(6):C1518-27
- 17. Min Young Lee, Sung Duk Jho, Jang Hern Lee, Ho Jae Han(2008) L-leucine increases [3H]-thymidine incorporation in chicken hepatocytes: Involvement of the PKC, ERK1/2, Akt, and mTOR signaling pathways. J Cell Biochem 105(6):1410-9
- 18. Mi Na Lee, Sang Hun Lee, Min Young Lee, Yun Hee Kim, Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Yu Jin Lee, Mi Ok Kim, Kwangsung Park, Ho Jae Han. (2008) Effect of dihydrotestosterone (DHT) on mouse embryonic stem cells under H2O2-induced oxidative stress. J Vet Sci 9(3):247-56
- 19. Lee MY, Han HJ. (2008) Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of rapamycin pathways in mouse embryonic stem cells. Int J Biochem Cell Biol 40:2421-30
- 20. Heo JS, Lee SH, Han HJ. (2008) Regulation of DNA synthesis in mouse embryonic stem cells by transforming growth factor-a : Involvement of PI3-K/Akt and Notch/Wnt signaling pathways. Growth Factors 26(2):104-16
- 21. Park JH, Lee MY, Heo JS, Han HJ. (2008) A potential role of connexin 43 in EGF-induced proliferation of mouse embryonic stem cells : Involvement of Ca2+/PKC, p44/42 and p38 MAPKs pathways. Cell Proliferation 41:786-802
- 22. Kim MO, Na SI, Lee MY, Heo JS, Han HJ. (2008) Epinephrine increases DNA synthesis via ERK1/2s through cAMP, Ca2+/PKC, and PI3K/Akt signaling pathways in mouse embryonic stem cells. J Cell Biochem 104(4):1407-20
- 23. Lee SH, Lee MY, Heo JS, Han HJ. (2008) Effect of dihydrotestosterone on hydrogen peroxide-induced apoptosis of mouse embryonic stem cells. J Cell Physiol 216(1):269-75
- 24. Lee SH, Lee MY, Lee JH, Han HJ. (2008) A potential mechanism for short time exposure to hypoxia-induced DNA synthesis in primary cultured chicken hepatocytes: correlation between Ca2+/PKC/MAPKs and PI3K/Akt/mTOR. J Cell Biochem 104(5):1598-611
- 25. Lee MY, Jung SC, Lee JH, Han HJ. (2008) Estradiol-17b protects against hypoxia-induced hepatocyte injury through receptor-dependent Bcl-2 as well as -independent antioxidant effect. Cell Res 18(4):491-499
- 26. Kim YH, Han HJ. (2008) High glucose-induced prostaglandin E2 and peroxisome proliferator-activated receptor promotes mouse embryonic stem cells proliferation. Stem Cells 26(3):745-55
- 27. Lee SH, Lee MY, Han HJ. (2008) Short-period hypoxia increases mouse embryonic stem cells proliferation through cooperation of arachidonic acid and PI3K/Akt signal pathways. Cell Proliferation 41(2):230-247
- 28. Suh HN, Lee SH, Heo JS, Lee MY, Lee YJ, Han HJ. (2008) High glucose induced translocation of aquaporin8 to chicken hepatocyte plasma membrane: Involvement of cAMP, PI3K/Akt, PKC, MAPKs, and microtubule. J Cell Biochem 103(4):1089-1100
- 29. Lee YJ, Han HJ. (2008) Albumin-stimulated DNA synthesis is mediated by Ca2+/PKC as well as EGF receptor-dependent p44/42 MAPKs and NF-kB signal pathways. Am J Physiol-Renal Physiol 294(3):F534-41
- 30. Kim YH, Han HJ. (2008) Synergistic effect of high glucose and ANG II on proliferation of mouse embryonic stem cells : Involvement of PKC and MAPKs as well as AT1 receptor. J Cell Physiol 215(2):374-382
- 31. Ahn YK, Ryu JM, Jeong HC, Kim YH, Jeong MH, Lee MY, Lee SH, Park JH, Yun SP, Han HJ. (2008) Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography. J Vet Sci 9(2):121-126
- 32. Kim MH, Kim MO, Heo JS, Kim JS, Han HJ. (2008) Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells. Apoptosis. 13(2):295-304
- 33. Lee YJ, Han HJ. (2008) Response to 'Glucose transport across the proximal tubule brush border membrane: Response to diabetes mellitus'. Kidney Int 73(3):362
- 34. Min JJ, Le UCN, Han HJ, Lee HS, Moon SM, Heo JS, Lee YJ, Ahn KY, Park KS (2008) Visualization of embryonic stem cell survival in vivo by adenviral biolumininescence receptor in rat corpus cavernosum. Tissue Engineering Regenerative Medicine 5(4-6):743-749
- 35. Hyoung-Sig Seo, Hyun-Woo Kim, Dae-Hyun Roh, Seo-Yeon Yoon, Young-Bae Kwon, Ho-Jae Han, Chung JM, Alvin Beitz, Jang-Hern Lee. (2008) A new rat model for thrombus-induced ischemic pain (TIIP); development of bilateral mechanical allodynia. Pain. 139:520-32
- 36. Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Lee JH. (2008) Intrathecal administration of sigma-1 receptor agonists facilitates nociception: Involvement of a protein kinase C-dependent pathway. J Neurosci Res 86(16):3644-54
- 37. Lim SK, Park MJ, Jung HK, Park AY, Kim DI, Kim JC, Bae CS, Kim KY, Yoon KC, Han HJ, Park SH. (2008) Bradykinin stimulates glutamate uptake via both B1R and B2R activation in human retinal pigment epithelial cells. Life Sci 83(23-24):761-70
- 38. Ren Xianghao, Yu Jin Lee, Ho Jae Han, In S Kim. (2008) Effect of tris-(2-chloroethyl)-phosphate (TCEP) at environmental concentration on the levels of cell cycle regulatory protein expression in primary cultured rabbit proximal tubule cells. Chemosphere 74:84-8
- 39. Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH. (2008) Intrathecal injection of the varsigma1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain. Anesthesiology. 109(5):879-89
- 40. Kang SY, Yoon SY, Roh DH, Jeon MJ, Seo HS, Uh DK, Kwon YB, Kim HW, Han HJ, Lee HJ, Lee JH. (2008) The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. J Pharm Pharmacol. 60(10):1347-54
- 41. Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Han HJ, Beitz AJ, Lee JH. (2008) Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain. Anesth Analg. 107(2):693-700
- 42. Kim HW, Roh DH, Yoon SY, Seo HS, Kwon YB, Han HJ, Kim KW, Beitz AJ, Lee JH. (2008) Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR 1 subunit in mice. British J Pharm 154: 1125-1134
- 43. Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Han HJ, Beitz AJ, Lee JH. (2008) Depletion of capsaicin sensitive afferents prevents lamina-dependent increases in spinal N-methyl-d-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats. Eur J Pain 12:552-563
- 44. Gong SP, Lee EJ, Lee ST, Kim HB, Lee SH, Han HJ, Lim JM (2008) Improved establishment of autologous stem cells derived from preantral follicle culture and oocyte parthenogenesis. Stem Cells and Develop 17(4):695-712
- 45. Kim HW, Uh Dk, Yoon SY, Roh DH, Kwon YB, Han HJ, Lee HJ, Beitz AJ, Lee JH (2008) Low-frequency electroacupuncture suppresses carrageenan-induced paw inflammation in mice via sympathetic post-ganglionic neurons, while high-frequency EA suppression is mediated by the sympathoadrenal medullary axis. Brain Res Bull. 75(5):698-705
- 46. Yoon SY, Kwon YB, Kim HW, Rho DH, Seo HS, Han HJ, Lee HJ, Beitz AJ, Lee JH. (2008) Bee venom injection produces a peripheral anti-inflammatory effect by activation of a nitric oxide-dependent spinocoeruleus pathway. Neurosci Lett. 430(2):163-168
- 47. Han HJ, Lim MJ, Lee YJ, Lee JH, Yang IS, Mary Taub. (2007) Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-kB. Am J Physiol-Renal Physiol 292(1):F373-381.
- 48. Lee MY, Lee SH, Lee SG, Park SH, Lee CY, Kim KH, Hwang SH, Lim SY, Ahn YK, Han HJ. (2007) Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography. J Vet Sci 8(1):7-14.
- 49. Lee SH, Heo JS, Han HJ. (2007) Effect of hypoxia on 2-deoxyglucose uptake and cell cycle regulatory protein expression of mouse embryonic stem cells: involvement of Ca2+/PKC, MAPKs, and HIF-1. Cell Physiol Biochem 19:269-282.
- 50. Han JY, Heo JS, Lee YJ, Lee JH, Mary Taub, Han HJ. (2007) Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells. J Cell Physiol 211(2):486-494.
- 51. Han HJ, Han JY, Heo JS, Lee SH, Lee MY, Kim YH. (2007) ANG II-stimulated DNA synthesis is mediated by ANG II receptor-dependent Ca2+/PKC as well as EGF receptor-dependent PI3K/Akt/mTOR/p70S6K1 signal pathways in mouse embryonic stem cells. J Cell Physiol 211(3):618-629.
- 52. Lee YJ, Lee YJ, Han HJ. (2007) Regulatory mechanisms of Na+/glucose cotransporters in renal proximal tubule cells. Kidney Int 72(S106):S27-S35.
- 53. Lee MY, Lee SH, Park JH, Heo JS, Lee YJ, Suh HN, Min JJ, Seo YS, Han HJ. (2007) Effectiveness of 99mTC-tetrofosmin for assessment of heart functions in micropigs. J Vet Sci 8(3):223-227.
- 54. Lee YJ, Heo JS, Suh HN, Han HJ. (2007) Interleukin-6 stimulates 14C-a-methyl-D-glucopyranoside uptake in renal proximal tubule cells: Involvement of STAT3, PI3K/Akt, MAPKs, and NF-kB. Am J Physiol-Renal Physiol 93(4):F1036-1046
- 55. Na SI, Lee MY, Heo JS, Han HJ. (2007) Hydrogen peroxide increased [3H]2-deoxyglucose uptake via MAPKs, cPLA2, and NF-κB signaling pathway in mouse embryonic stem cells. Cell Physiol Biochem 20:1007-1018
- 56. Heo JS, Lee MY, Han HJ. (2007) Sonic hedgehog stimulates mouse embryonic stem cell proliferation by cooperation of Ca2+/Protein Kinase C and EGF receptor as well as Gli1 activation. Stem Cells 25(12):3069-3080
- 57. Kim DI, Lim SK, Park MJ, Han HJ, Kim GY, Park SH. (2007) The involvement of phosphatidylinositol 3-kinase /Akt signaling in high glucose-induced downregulation of GLUT-1 expression in ARPE cells. Life Sci 80(7):626-632.
- 58. Kim HW, Kang SY, Yoon SY, Roh DH, Kwon YB, Han HJ, Lee HJ, Alvin J Beitz, Lee JH. (2007) Low frequency electroacupuncture suppresses zymosan-induced peripheral inflammation via activation of sympathetic post-ganglionic neurons. Brain Res 1148:69-75.
- 59. Yoon SY, Kwon YB, Kim HW, Roh DH, Seo HS, Han HJ, Lee HJ, Beitz AJ, Hwang SW, Lee JH. (2007) Peripheral bee venom's anti-inflammatory effect involves activation of the coeruleospinal pathway and sympathetic preganglionic neurons. Neuroscience Research 59(1):51-59.
- 60. Lee GS, Choi KC, Han HJ, Jeung EB. (2007) The classical and a non-classical pathways associated with NF-κB are involved in estrogen-medicated regulation of calbindin-D9k gene in rat pituitary cells. Mol Cell Endocrinol 277:42-50
- 61. Yoon SY, Kwon YB, Kim HW, Roh DH, Seo HS, Han HJ, Beitz AJ, Lee JH (2007) A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice. Neuropharmacology 53(5):677-686
- 62. Park KS, Han HJ, Kim SW, Jung SI, Kim SO, Lee HS, Lee MN, Ahn KY (2007) Expression of aquaporin water channels in rat vagina: Potential role in vaginal lubrication. J Sex Med 5(1):77-82
- 63. Heo JS, Lee YJ, Han HJ. (2006) EGF stimulates proliferation of mouse embryonic stem cells : Involvement of Ca2+ influx and p44/42MAPKs. Am J Physiol-Cell Physiol 290(1):C123-C133.
- 64. Han HJ, Heo JS, Lee YJ, Min JJ, Park KS. (2006) High glucose-induced inhibition of 2-deoxyglucose uptake is mediated by cAMP, PKC, oxidative stress, and MAPKs in mouse embryonic stem cells. Clinic Exp Physiol Pharmacol 33(3):211-220.
- 65. Han HJ, Heo JS, Lee YJ. (2006) Estradiol-17β stimulates proliferation of mouse embryonic stem cells (ES-E14TG2a): Involvement of MAPKs and CDKs as well as protooncogenes. Am J Physiol-Cell Physiol 290:C1067-C1075.
- 66. Heo JS, Han HJ. (2006) PKC and MAPKs pathways mediate EGF-induced stimulation of 2-deoxyglucose uptake in mouse embryonic stem cells. Cell Physiol Biochem 17:145-158.
- 67. Lee MY, Heo JS, Han HJ. (2006) Dopamine regulates cell cycle regulatory proteins via cAMP, Ca2+/PKC, MAPKs, and NF-kB in mouse embryonic stem cells. J Cell Physiol 208(2):399-406.
- 68. Lee YJ, Han HJ. (2006) Role of ATP on DNA synthesis of renal proximal tubule cells:Involvement of calcium, MAPKs, and CDKs. Am J Physiol-Renal Physiol 291(1):F98-F106.
- 69. Han HJ, Park SH (2006) Alteration of the gene and protein levels of insulin-like growth factors in streptozotocin-induced diabetic male rats. J Vet Med Sci 68(5):413-419.
- 70. Lee MY, Park SH, Heo JS, Lee JH, Han HJ. (2006) EGF-induced inhibition of glucose transport is mediated by PKC and MAPKs signal pathways in primary cultured chicken hepatocytes. Am J Physiol-Gastrology and Liver Physiol 291(4):G744-750.
- 71. Kim YH, Heo JS, Han HJ. (2006) High glucose increased cell cycle regulatory protein levels of mouse embryonic stem cells via PI3-K/Akt and MAPKs signal pathways. J Cell Physiol. 209(1):94-102.
- 72. Lee MY, Lee SH, Kim YH, Heo JS, Park SH, Lee JH, Han HJ. (2006) Effect of EGF on [3H]thymidine incorporation and cell cycle regulatory proteins in primary cultured chicken hepatocytes: Involvement of Ca2+/PKC and MAPKs. J Cell Biochem 99(6):1677-1687.
- 73. Lee YJ, Lee JH, Han HJ. (2006) Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21WAF1/Cip1 and p27Kip1 expression in primary cultured renal proximal tubule cells: Role of PI3K and Akt signaling. J Cell Physiol 209(3):802-810.
- 74. Heo JS, Han HJ. (2006) ATP stimulates mouse embryonic stem cell proliferation via PKC, PI3K/Akt, and MAPKs signaling pathways. Stem Cells 24(12):2637-2648.
- 75. Han HJ, Kang CW, Park SH. (2006) Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro. Clin Exp Pharmacol Physiol 33(12):1172-1179.
- 76. Kim HW, Roh DH, Yoon SY, Kwon YB, Kang SY, Han HJ, Lee HJ, Choi SM, Ryu YH, Beitz AJ, Lee JH. (2006) The Anti-inflammatory Effects of Low and High Frequency Electroacupuncture are Mediated by Peripheral Opioids in a Mouse Air Pouch Inflammation Model. J Altern Complement Med 12(1):39-44.
- 77. Lee ST, Han HJ, Oh SJ, Lee EJ, Han JY, Lim JM. (2006) Influence of ovarian hyperstimulation and ovulation induction on the cytoskeletal dynamics and developmental competence of oocytes. Mol Reprod Dev 73(8):1022-1033
- 78. Kwon YB, Yoon SY, Kim HW, Roh DH, Kang SY, Ryu YH, Choi SM, Han HJ, Lee HJ, Kim KW, Beitz AJ, Lee JH. (2006) Substantial role of locus coeruleus-noradrenergic activation and capsaicin insensitive primary afferent fibers in bee venom’s anti-inflammatory effect. Neurosci Res 55(2):197-203.
- 79. Roh DH, Kim HW, Yoon SY, Kang SY, Kwon YB, Cho KH, Han HJ, Ryu YH, Choi SM, Lee HJ, Beitz AJ, Lee JH. (2006) Bee venom injection significantly reduces nociceptive behavior in the mouse formalin test via capsaicin-insensitive afferents. J Pain 7(7):500-512.
- 80. Yoon SY, Kim HW, Roh DH, Kwon YB, Han HJ, Beitz AJ, Lee JH. (2006) Intrathecal clonidine suppresses zymosan-induced peripheral leukocyte migration in a mouse air pouch model via activation of spinal muscarinic type 2 receptors and sympathoadrenal medullary activity. Neuropharmacology 51(4):829-837.
- 81. Kim HW, Kwon YB, Roh DH, Yoon SY, Han HJ, Kim KW, Beitz AJ, Lee JH. (2006) Intrathecal treatment with sigma1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice. Br J Pharmacol. 148:490-498
- 82. Lee ST, Oh SJ, Lee EJ, Han HJ, Lim JM. (2006) Adenosine triphosphate synthesis, mitochondrial number and activity, and pyruvate uptake in oocytes following gonadotropin injections. Fertility & Sterility 86(4):1164-1169.
- 83. Han HJ, Oh YJ, Lee YJ. (2005) Effect of albumin 14C-α-methyl-D-glucopyranoside uptake in primary cultured renal proximal tubule cells: Involvement of PLC, MAPK, and NF-kB. J Cell Physiol 202:246-254.
- 84. Han HJ, Lee MJ, Lee YJ, Lee EJ, Jeon YJ, Lee JH. (2005) Effects of TCDD and estradiol-17β on the proliferation and Na+/glucose cotransporter in renal proximal tubule cells. Toxicol In Vitro 19:21-30.
- 85. Han HJ, Lee YJ, Park JY, Kim EJ, Lee JH, Mary Taub. (2005) Effect of EGF on H2O2-induced inhibition of α-MG uptake in renal proximal tubule cells: Involvement of MAPK and AA release. J Cell Physiol 203:217-225.
- 86. Han HJ, Lee YJ, Park SY, Lee JH, Mary Taub. (2005) High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cells. Am J Physiol-Renal Physiol 288:F988-F996.
- 87. Han HJ, Lee YJ. (2005) Insulin stimulates Ca2+ uptake via PKC, cAMP, and p38 MAPK in mouse embryonic stem cells. Life Sci 76(25):2903-2919.
- 88. Lee YJ, Han HJ. (2005) Effect of adenosine triphosphate in renal ischemic injury: Involvement of NF-kB. J Cell Physiol 204:792-799.
- 89. Lee YJ, Park SH, Jung TO, Kim KW, Lee JH, Han HJ. (2005) Effect of adenosine triphosphate on phosphate uptake in renal proximal tubule cells : Involvement of PKC and p38 MAPK. J Cell Physiol 205:68-76.
- 90. Han HJ, Heo JS, Lee YJ. (2005) ANG II increases 2-deoxyglucose uptake in mouse embryonic stem cells. Life Sciences 77:1916-1933.
- 91. Lee YJ, Park SH, Han HJ. (2005) Adenosine triphosphate (ATP) stimulates Na+/glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells. Am J Physiol-Cell Physiol 289:C1268-C1276.
- 92. Kwon YB, Kim HW, Han HJ, Yang IS, Alvin J. Beitz And Lee JH. (2005) Antinociceptive Mechanisms associated with Diluted Bee Venom Acupuncture (Apipuncture) in the Rat Formalin Test: Involvement of Descending Adrenergic and Serotonergic Pathways. Pharmacol Res 51(2):183-188.
- 93. Kwon YB, Ham TW, Kim HW, Roh 오, Yoon SY, Han HJ, Yang IS, Kim KW, Alvin J. Beitz, Lee JH. (2005) Water soluble fraction (10 kDa) from bee venom reduces visceral pain behavior through spinal α2-adrenergic activity in mice. Pharmacol Biochem Behavior 80:181-187.
- 94. Seo ES, Kim D, Han HJ. (2005) Enzymatic synthesis and anti-coagulant effect of salicin analogs by using the Leuconostoc mesenteroides glucansucrase acceptor reaction. Journal of Biotechnology 117(1):31-38.
- 95. Yoon SY, Kim HW, Roh DH, Kwon YB, Jung TO, Han HJ, Lee HJ, Choi SM, Ryu YH, Beitz AJ, Lee JH. (2005) The anti-inflammatory effect of peripheral bee venom stimulation is mediated by central muscarinic type 2 receptors and activation of sympathetic preganglionic neurons. Brain Res 1049:210-216.
- 96. Han HJ, Park SH, Lee YJ. (2004) Signaling cascade of ANG II-induced inhibition of a-MG uptake in renal proximal tubule cells. Am J Physiol-Renal Physiol 286:F634-F642.
- 97. Han HJ, Park JY, Lee YJ, Mary Taub. (2004) Epidermal growth factor inhibits 14C-a-methyl-D-glucopyranoside uptake in renal proximal tubule cells: Involvement of PLC/PKC, p44/42 MAPK, and cPLA2. J Cell Physiol 199:206-216.
- 98. Han HJ, Wade J Sigurdson, Peter A Nickerson, Mary Taub. (2004) Both mitogen activated protein kinase and the mammalian target of rapamycin modulate the development of functional renal proximal tubules in matrigel. J Cell Sci 117:1821-1833.
- 99. Park SH, Lee YJ, Im MJ, Kim EJ, Han HJ. (2004) High glucose inhibits fructose uptake in renal proximal tubule cells: Involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2. J Cell Physiol 200:407-416.
- 100. Lee YJ, Lee JH, Han HJ. (2004) Ethanol-inhibited [3H]thymidine incoporation via protein kinase C-p44/42 mitogen-activated portien kinase/phospholipase A2 signal pathway in renal proximal tubule cells. Alcoholism: Clinic Exp Res 28:1172-1179.
- 101. Han HJ, Lim MJ, Lee YJ. (2004) Oxalate inhibits renal proximal tubule cell proliferation via oxidative stress, p38 MAPK/JNK, and cPLA2 signaling pathways. Am J Physiol-Cell Physiol 287:C1058-C1066.
- 102. Kim EJ, Lee YJ, Lee JH, Han HJ. (2004) Effect of epinephrine on α-methyl-D-glucopyranoside uptake in renal proximal tubule cells. Cell Physiol Biochem 14:395-406.
- 103. Kwon YW, Han HJ, Albin J. Beitz, Lee JH. (2004) Bee venom acupoint stimulation increases Fos expression in catecholaminergic neurons in the rat brain. Mol Cells 17(2):111-119.
- 104. Roh DH, Kwon YB, Kim HW, Ham TW, Yoon SY, Kang SY, Han HJ, Lee HJ, Beitz Alvin J. and Lee JH. (2004) Acupoint stimulation with diluted bee venom (Apipuncture) alleviates thermal hyperalgesia in a rodent neuropathic pain model: Involvement of spinal alpha 2-adrenoceptors. J of Pain 5(6):297-303.
- 105. Han HJ, Park SH, Lee YJ. (2003) EGF regulates Ca2+ uptake in primary cultured renal proximal tubule cells: Involvement of cAMP, PKC, cPLA2. Kidney and Blood Pressure Research 26(3):155-164.
- 106. Han HJ, Park SH, Lee YJ, Lee JC, Lee JH. (2003) Effect of ATP on Ca2+ uptake in presence of high glucose in renal proximal tubule cells. Clinic Exp Physiol Pharmacol 30(9):694-701.
- 107. Han HJ, Park JY, Lee YJ, Park SH. (2003) Effect of epidermal growth factor on phosphate uptake in renal proximal tubule cells : Involvement of PKC, MAPK, and cPLA2. Kidney and Blood Pressure Research 26(5-6):315-324.
- 108. Han HJ, Jeon YJ, Lee YJ. (2003) Involvement of NF-kB in high glucose-induced alteration of α-methyl-D-glucopyranoside (α-MG) uptake in renal proximal tubule cells. Cell Physiol Biochem 13:375-384.
- 109. Kwon YB, Hyun Woo Kim, Ham TW, Yoon SY , Rho DH, Han HJ, Alvin J. Beitz, Yang IS, Lee JH. (2003) The anti-inflammatory effect of bee venom stimulation in a mouse air pouch model is mediated by adrenal medullary activity. J Neuroendocrinology 15(1):93-96.
- 110. Kim HW, Kwon YB, Ham TW, Rho DH, Yoon SY, Lee HJ, Han HJ, Yang IS, Alvin J Beitz, Lee JH. (2003) Acupoint stimulation using bee venom attenuates formalin-induced pain behavior and spinal cord fos expression in rats. J Vet Med Sci 65(3):349-355
- 111. Nam KW, Je KH, Lee JH, Han HJ, Lee HJ, Kang SK, Mar W. (2003) Inhibition of COX-2 activity and proinflammatory cytokines (TNF-alpha and IL-1beta) production by water-soluble sub-fractionated parts from bee (Apis mellifera) venom. Arch Pharm Res 26(5):383-388.
- 112. Park SH, Han HJ. (2002) The Mechanism of angiotensin II binding downregulation by high glucose in primary renal proximal tubule cells. Am J Physiol-Renal Physiol 282(2):F228-F237.
- 113. Han HJ, Park SH, Park HJ, Park KM, Kang JW, Lee JH, Lee BC, Hwang WS. (2002) Effect of various Oestrogens on cell injury and alteration of apical transporters induced by tert-butyl hydroperoxide in renal proximal tubule cells. Clinical and Experimental Physiology and Pharmacology 29(1-2):60-67.
- 114. Park SH, Woo CH, Kim JH, Lee JH, Yang IS, Park KM Han HJ (2002) High glucose down-regulates angiotensin II binding via PKC-MAPK-cPLA2 signal cascade in renal proximal tubule cells. Kidney Int 61(3):913-925.
- 115. Han HJ, Park SH, Lee JH, Yoon BC, Park KM, Mar WC, Lee HJ, Kang SK. (2002) Involvement of oxidative stress in bee venom-induced inhibition of Na+/glucose cotransporter in renal proximal tubule cells. Clinical and Experimental Physiology and Pharmacology 29:564-568.
- 116. Han HJ, Park SH, Park KM, Yoon BC, Kim TS, Lee JH. (2002) Effect of caffeic acid on apical transporters' dysfunction of renal proximal tubule cells under oxidative stress in vitro. Planta Medica 68(6):483-486.
- 117. Han HJ, Lee YH, Park KM and Mary Taub. (2002) Estradiol-17β stimulates phosphate uptake and is mitogenic for primary rabbit renal proximal tubule cells. Exp Nephrol 10(5-6):355-364.
- 118. Han HJ, Yoon BC, Park SH, Park JY, Oh YJ, Lee YJ, Park KM. (2002) Ginsenosides protect apical transporters of cultured proximal tubule cells from dysfunctions induced by H2O2. Kidney and Blood Pressure Research 25(5):308-314.
- 119. Han HJ, Yoon BC, Lee JH, Park SH, Park JY, Oh YJ, Lee YJ. (2002) Ginsenosides inhibit EGF-induced proliferation of renal proximal tubule cells via decrease of c-fos and c-jun gene expression in vitro. Planta Medica 68(11):971-974.
- 120. Han HJ, Yoon BC, Oh YJ, Park SH, Lee JH, Mar WC. (2002) The water soluble fraction (10 KDa) of bee venom (Apis mellifera) produces inhibitory effect on apical transporters in renal proximal tubule cells. Kidney and Blood Pressure Research 25:375-383.
- 121. Kwon YB, Lee HJ, Han HJ, Mar WC, Kang SK, Yoon OB, Alvin J. Beitz, Lee JH. (2002) The water-soluble fraction of bee venom produces antinociceptive and anti-inflammatory effects on rheumatoid arthritis in rats. Life Sciences 71: 191-204.
- 122. Kim HW, Kwon YB, Ham TW, Roh DH, Yoon SY, Han HJ, Kim KW, Lee WS, Kim JK, and Lee JH. (2002) Distribution of Nociceptin-like Immunoreactivity in the Central Nervous System of the Mongolian Gerbil; an Immunohistochemical study. Anat. Histol. Embryol 31(3):187-192.
- 123. Mary Taub, Han HJ, Trivikaram Rajkhowa, Cheryl Allen, Park JH. (2002) Clonal analysis of immortalized renal proximal tubule cells: Na+/glucose cotransport system levels are maintained despite a decline in transport function. Experimental Cell Research 281:205-212.
- 124. Park SH, Mary Taub, Han HJ. (2001) Regulation of phosphate uptake in primary cultured rabbit renal proximal tubule cells by glucocorticoids: Evidence for nongenomic as well as genomic mechanisms. Endocrinology 142(2);710-720.
- 125. Park SH, Choi HJ, Lee JH, Yang IS, Han HJ. (2001) High glucose stimulates Ca2+ uptake via cAMP and PLC/PKC pathways in primary cultured renal proximal tubule cells. Kidney & Blood Pressure Research 24(1);10-17.
- 126. Park SH, Choi HJ, Lee JH, Woo CH, Kim JH, Han HJ. (2001) High glucose inhibits renal proximal tubule cell proliferation and Involves protein kinase C, oxidative stress, and transforming growth factor-β1. Kidney Int 59(5);1695-1705.
- 127. Park SH, Shin SS, Han HJ. (2001) High glucose levels alters angiotensin II-induced Ca2+ uptake via PKC and cAMP pathways in renal proximal tubular cells. Kidney & Blood Pressure Research 24(2);84-91.
- 128. Han HJ, Park SH, Park HJ, Lee JH, Lee BC, Hwang WS. (2001) Effects of sex steroid hormones on Na+/glucose cotransporter of renal proximal tubular cells following oxidant injury. Kidney & Blood Press Res 24(3):159-165.
- 129. Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, Kang 나, Alvin J. Beitz, Lee JH. (2001) Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive response Pain 90(3);271-280.
- 130. Lee JH, Kwon YB, Han HJ, Mar WC, Lee HJ, Yang IS, Alvin J. Beitz, Kang 나. (2001) Bee venom pretreatment has both an antinociceptive and anti-inflammatory effect on carrageenan-induced inflammation. J Vet Med Sci 63(3);251-259.
- 131. Kwon YB, Kang MS, Kim HW, Ham TW, Yim YK, Jeong SH, Park DS, Choi 요, Han HJ, Alvin J. Beitz, Lee JH. (2001) Antinociceptive effects of bee venom acupuncture (Apipuncture) in rodent animal models: A comparative study of acupoint versus non-acupoint stimulation. Acupuncture & Electrotherapeutics Res 26(1-2);59-68.
- 132. Kwon YB, Kang MS, Han HJ, Alvin J. Beitz, Lee JH. (2001) Visceral Antinociception Produced By Bee Venom Stimulation of the Zhongwan Acupuncture Point In Mice: Role of α2 adrenoceptors. Neurosci. Lett 308:133-137.
- 133. Kwon YB, Kim JH, Yoon JH, Lee JD, Han HJ, Mar WC, Alvin J Beitz, Lee JH. (2001) The analgesic efficacy of bee venom acupuncture for knee osteoarthritis: a comparative study with needle acupuncture. Am J Chinese Med 29(2):187-199.
- 134. Han HJ, Choi HJ, Park SH. (2000) High glucose-induced inhibition of α-methyl-D-glucopyranoside uptake is mediated by protein kinase C-dependent activation of arachidonic acid release in primary cultured rabbit renal proximal tubule cells. J Cell Physiol 183:355-363.
- 135. Han HJ, Choi HJ, Park SH. (2000) High glucose inhibits glucose uptake in renal proximal tubule cells by oxidative stress and protein kinase C. Kidney Int 57:918-926.
- 136. Han HJ, Park SH, Koh HJ, Mary Taub. (2000) Mechanism of regulation of Na+ transport by angiotensin II in primary renal cells. Kidney Int 57(6):2457-2467.
- 137. Han HJ, Lee YH, Park SH. (2000) Estradiol-17β-BSA stimulates Ca2+ uptake through nongenomic pathways in primary rabbit kidney proximal tubule cells: Involvement of cAMP and PKC. J Cell Physiol 183:37-44.
- 138. Han HJ, Kim DH, Park SH. (2000) Regulatory mechanism of Na/Pi cotransport by glucocorticoid in renal proximal tubule cells: Involvement of cAMP and PKC. Kidney & Blood Pressure Research 23:1-9.
- 139. Han HJ, Lee JH, Park SH, Choi HJ, Yang IS, Mar WC, Kang SK, Lee HJ (2000) Effect of bee venom and its melitin on apical transporters of renal proximal tubule cells. Kidney & Blood Pressure Research 23(6):393-399.
- 140. Choi K, Park SW, Lee KJ, Lee HB, Han HJ, Park SK, Park HS. (2000) Grass carp (Ctenopharyngodon idellus) bile may inhibit the release of renal dipeptidase from the proximal tubules by nitric oxide generation. Kidney & Blood Pressure Research 23(2):113-118.
- 141. Kwon YB, Kang MS, Ahn CJ, Han HJ, Ahn BC, Lee JH. (2000) Effect of high or low frequency electroacupuncture on the cellular activity of catecholaminergic neurons in the brain stem. Acupuncture & Electrotherapeutics Res 25:27-36.
- 142. Kwon YB, Yang IS, Kang KS, Han HJ, Lee YS, Lee JH. (2000) Effects of dizocilpine pretreatment on parvalbumin immunoreactivity and Fos expression after cerebral ischemia in the hippocampus of the Mongolian gerbil. J Vet Med Sci 62(2):141-146.
- 143. Lee JH, Kim HW, Kwon YB, Kang MS, Choi DW, Na JH, Kwon OK, Youn HJ, Han HJ, Byun TH, Park SY, Chun BH, Pyun JH, An JH, Lee YJ, Cho MH. (2000) General pharmacology studies on β-domain deleted recombinant factor VIII. Arzneimittel-Forschung/Drug Research 50(1):86-92.
- 144. Woo CH, Eom YW, Yoo MH, You HJ, Han HJ, Song WK, Yoo YJ, Chun JS, Kim JH. (2000) Tumor necrosis factor-α generates reactive oxygen species via a cytosolic phospholipaseA2-linked cascade. J Biol Chem 275:32357-32362.
- 145. Kwon YB, Kang MS, Son SS, Kim JT, Lee YH, Han HJ, Lee JH. (2000) Different frequencies of electroacupuncture modified the cellular activity of serotonergic neurons in brainstem. Am J Chinese Med 28(3-4):435-441.
- 146. Han HJ, Jung JC, Mary Taub. (1999) Response of primary rabbit kidney proximal tubule cells to estrogens. J Cell Physiol 178:35-43.
- 147. Han HJ, Park SH, Koh HJ, Nah SY, Shin DH, Choi HS (1999) Protopanaxatriol ginsenosides inhibit glucose uptake in primary cultured rabbit renal proximal tubular cells by arachidonic acid release. Kidney & Blood Pressure Research 22(3):114-120.
- 148. Han HJ, Park SH, Lee JC, Lee HH, Park HS. (1999) Leukotrien D4 inhibits Na+ uptake through cAMP and PLC pathways in the primary cultured renal proximal tubular cells. Kidney & Blood Pressure Research 22(3) :106-113.
- 149. Han HJ, Koh HJ, Park SH. (1999) A signaling pathway for stimulation of Na+ uptake induced by angiotensin II in primary cultured rabbit renal proximal tubule cells. J Vet Med Sci 61(2):135-141.
- 150. Han HJ, Kim DH, Park SH, Lee YS, Lee JH, Yang IS. (1999) Regulatory mechanism of polarized membrane transport by glucocorticoid in renal proximal tubule cells: Involvement of [Ca2+]i. J Vet Med Sci 61(11):1197-1202.
- 151. Kwon YB, Yoon SY, Han HJ, Lee JH. (1999) Effect of 7-nitroindazole, a selective neuronal nitric oxide synthase inhibitor, on parvalbumin immunoreactivity after cerebral ischaemia in the hippocampus of the Mongolian gerbil. Anatomia Histologia Embryologia 28:3
- 152. Kang BY, We JS, Choi K, Lee HB, Han HJ, Park HS. (1999) Release of renal dipeptidase from rabbit renal proximal tubules and its inhibition by gentamicin. Arch Pharm Res 22(4):367-371.
- 153. Han HJ, Lee YH, Park SH, Choi HJ, Son CH, Yoon YD. (1999) Estradiol-17β stimulates Ca2+ uptake through nongenomic action in renal proximal tubule cells. Recent Progress in Molecular and Comparative Endocrinology 515-521.