수의바이러스학교실은 동물의 바이러스 감염 메커니즘, 바이러스-숙주 상호작용, 바이러스의 병독성 인자 및 면역 회피 기전부터 바이러스 진단법, 바이러스 백신 및 치료제 개발 등을 아우르는 바이러스 감염병에 대한 다양하고 종합적인 지식을 전달하는 것을 목표로 한다.

1. Mechanistic evaluation of innate-like CD8+ memory T cells and their therapeutic potentials in viral diseases

2. Host-pathogen interaction with specific emphasis on T cells in immune suppressive viral infection

3. Application of immunotherapeutics in chronic conditions 

4. In vivo immune cell reprogramming

1. Lim SY*, Lee J*, Osuna CE, VikheP, Schalk DR, Chen E, Fray E, Kumar M, Schultz-Darken N, Rakasz E, Capuano S, Ladd RA, Gil HM, Evans D, Evans DT, Jeng E, Seaman M, Martin MA, Van Dorp C, Wong H, Perelson A, Siliciano JD, Silicaino, R, Safrit J, Nixon DF, Soon-Shiong P, Nussenzweig MC, Whitney JB. Induction of durable remission by combination immunotherapy in SHIV infected, ART-suppressed macaques. Science. 2024 Mar 8;383(6687):1104-1111. *Equal contribution

2. Lee J, Whitney JB. Immune checkpoint inhibition as a therapeutic strategy for HIV eradication: current insights and future directions. Curr Opin HIV AIDS. 2024 Jul 1;19(4):179-186.

3. Lee J, Jung BG, Lee BJ. Nasally delivered chitosan-coated poly(lactide-co-glycolide) encapsulating honeybee venom enhances T helper 1-related immunity against Salmonella Typhimurium infection in pigs. Am J Vet Res. 2024 Jun 20;85(9):ajvr.24.03.0086. 

4. Park BM*, Lee J*, Park YK, Yang YC, Jung BG, Lee BJ. Immune-enhancing effects of chitosan-fermented feed additive on broiler chickens and subsequent protection conferred against experimental infection with Salmonella Gallinarum. J Poult Sci. 2023 Jul. 60(2):2023016. *Equal contribution

5. Ishida E, Lee J, Campbell JS, Chakravarty DP, Katori Y, Takenori O, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI. Intratumoraldelivery of an HPV vaccine elicits a broad anti-tumor immune response that translated into a potent anti-tumor effect. Cancer Immunol Immunother. 2019 Aug. 68(8):1273-1286.

6. Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting a-catenin/CBP activity in head and neck cancer. Genome Med. 2018 Jul. 10(1):54.

7. Lee J, Kim YM, Kim JH, Cho CW, Jeon JW, Park JK, Lee SH, Kim SK, Jung BG, Lee BJ. Nasal delivery of chitosan/alginate nanoparticle encapsulated bee (Apis mellifera) venom promotes antibody production and viral clearance during porcine reproductive and respiratory syndrome virus infection by modulating T cell related responses. Vet Immunol Immunopathol. 2018 Jun. 200: 40-51.

8. Lee J, Kim YM, Park YK, Yang YC, Jung BG, Lee BJ. Black soldier fly (Hermetia illucens) larvae enhances immune activities and increases survivability of broiler chicks against experimental infection of Salmonella Gallinarum. J Vet Med Sci. 2018 May. 80(5): 736-740.

9. Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Lyengar NM, Pai SI. PD-1 Expression in head and neck squamous cell carcinomas derives primarily from functionally anergic CD4+ TILs in the presence of PD-L1+ TAMs. Cancer Res. 2017 Nov. 77(22): 6365-6374. 

10. Lee JA, Kim YM, Kim TH, Lee SH, Lee CA, Cho CW, Jeon JW, Park JK, Kim SK, Jung BG, Lee BJ. Nasal delivery of chitosan-coated poly(lactide-co-glycolide)-encapsulated honeybee (Apis mellifera) venom promotes Th 1-specific systemic and local intestinal immune responses in weaned pigs. Vet Immunol Immunopathol. 2016. 178: 99-106. 

11. Lee JA, Kim YM, Hyun PM, Jeon JW, Park JK, Suh GH, Jung BG, Lee BJ. Honeybee (Apis mellifera) venom reinforces viral clearance during the early stage of infection with porcine reproductive and respiratory syndrome virus through the up-regulation of Th1-specific immune responses. Toxins. 2015. 7: 1837-1853.

12. Lee JA, Jung BG, Kim TH, Kim YM, Koh HB, Lee BJ. Improvement of bacterial clearance and relief of clinical signs of Salmonella enterica serovar Typhimurium infection in pigs through upregulation of Th1-specific responses by administration of a combination of two silicate minerals, biotite and bentonite. J Vet Med Sci. 2015. 77(9): 1087-1094.

13. Lee JA, Jung BG, Kim TH, Kim YM, Park MH, Hyun PM, Jeon JW, Park JK, Cho CW, Suh GH, Lee BJ. Poly D,L-lactide-co-glycolide (PLGA) nanoparticle-encapsulated honeybee (Apis melifera) venom promotes clearance of Salmonella enterica serovar Typhimurium infection in experimentally challenged pigs through the up-regulation of Th 1 specific immune responses. Vet Immunol Immunopathol. 2014. 161(3-4): 193-204.

14. Lee JA, Jung BG, Jung MH, Kim TH, Yoo HS, Lee BJ. Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs. J Vet Sci. 2014. 15(3): 443-447.

15. Lee JA, Jung BG, Kim TH, Lee SG, Park YS, Lee BJ. Dietary feeding of Opuntia humifusainhibits UVB radiation-induced carcinogenesis by reducing inflammation and proliferation in hairless mouse model. Photochem Photobiol. 2013. 89(5): 1208-1215. 

16. Lee JA, Ko JH, Jung BG, Kim TH, Hong JI, Park YS, Lee BJ. Fermented Prunus mumewith probiotics inhibits 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl phorbol-13-acetate induced skin carcinogenesis through the alleviation of oxidative stress. Asian Pac J Cancer Prev. 2013. 14(5): 2973-2978. 

17. Lee JA, Jung BG, Lee BJ. Inhibitory effects of Opuntia humifusaon 7, 12- dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate induced two stage skin carcinogenesis. Asian Pac J Cancer Prev. 2012. 13(9): 4655-4660.