fnctId=prof,fnctNo=346 백영빈(Yeong-Bin Baek) 직위(직급) 교수 연구실 수의병리학교실 교수전공 및 연구분야 Veterinary Pathology, Molecular Virology, Host-Microbe Interactions, Antiviral Therapeutics 연락처 062-530-2844 이메일 ybbaek@jnu.ac.kr 홈페이지 - 학위 및 주요경력 03/2018 - 02/2014 Doctor of Veterinary Medicine (DVM) Chonnam National University 03/2014 - 02/2023 Doctor of Philosophy (PhD) College of Veterinary Medicine, Chonnam National University 03/2023 - 08/2023 Post-Doctoral Fellowships Chonnam National University Korea Research Institute of Bioscience & Biotechnology 09/2023 - Present Assistant Professor (Veterinary Pathology) College of Veterinary Medicine, Chonnam National University 연구실 소개 Veterinary pathology is a comprehensive discipline that delves into the principles of disease. It encompasses the nature and causes of diseases, the examination of morphological and functional changes in cells during disease progression, and the learning of disease diagnosis techniques to treat and prevent illnesses. Our aim is to achieve these goals seamlessly. Our laboratory in veterinary pathology is responsible for bridging the gap between basic and clinical subjects. We achieve this by accurately diagnosing various diseases and tumors that occur in companion and industrial animals, thereby contributing to clinical medicine. Furthermore, we are devoted to studying the mechanisms of disease development by identifying cellular and molecular etiology, thus contributing to the development of life sciences. The system of veterinary pathology is divided into diagnostic pathology and experimental pathology. Diagnostic pathology plays a crucial role in clinical medicine by providing quick and accurate diagnoses for various infectious and non-infectious diseases and tumors in multiple animals. Additionally, it can help prevent significant economic losses to farms by suggesting appropriate prevention and treatment directions for industrial animals. Experimental pathology, on the other hand, delves into the etiology, the development of new vaccines and diagnostic methods, and the development mechanisms of various tumors at the cellular and molecular level. For education, every semester, we offer 15-week courses consisting of lectures, necropsy, and microscopy practice, and seminars are taught in undergraduate and graduate courses to ensure that students receive comprehensive training in veterinary pathology. 주요연구분야 I have studied the pathogenesis of animal diseases, including infectious, metabolic, and neoplastic diseases, including those in humans. Currently, I am focusing on the study of zoonotic viruses, specifically influenza viruses and coronaviruses, to develop antiviral therapeutics and understand their mechanism of action. My aim is to gain further professional experience in molecular biology, pathology, microbiology, and host-microorganism interaction to contribute to disease prevention and control. In addition to my studies, I also engage in major extension activities that involve diagnosing domestic and companion animal diseases using histopathology, molecular biology, virology, bacteriology, and other techniques. 연구업적(주저자논문) 1. Baek YB, Kwon HJ, Sharif M, Lim J, Lee IC, Ryu YB, Lee JI, Kim JS, Lee YS, Kim DH, Park SI, Kim DK, Kim JS, Choy HE, Lee S, Choi HS, Osborne TF, Jeon TI, Cho KO. Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus. Signal Transduct. Target. Ther. 7(1): 367 (2022). 2. Sharif M, Baek YB, Naveed A, Stalin N, Kang MI, Park SI, Soliman M, Cho KO. Porcine Sapovirus-Induced Tight Junction Dissociation via Activation of RhoA/ROCK/MLC Signaling Pathway J. Virol. 95(11): e00051-21 (2021). 3. Soliman M, Seo JY, Baek YB, Park JG, Kang MI, Cho KO, Park SI. Opposite Effects of Apoptotic and Necroptotic Cellular Pathways on Rotavirus Replication. J. Virol. 96(1): e0122221 (2022). 4. Eom S, Lee J, Baek YB, Yeom HD, Lee S, Kim C, Park Y, Park SI, Lee CM, Lee JH. Identification and molecular study on the interaction of Schisandrin C with human 5-HT3A receptor. Eur. J. Pharmacol. 906: 174220 (2021). 5. Sharif M, Baek YB, Nguyen TH, Soliman M, Cho KO. Porcine sapovirus-induced RIPK1-dependent necroptosis is proviral in LLC-PK cells. PLos one. 18(2): e0279843 (2023). 6. Baek YB, Ang MJ, Park JG, Yu D, Park S, Lee JH, Choi J, Cho KO. Canine adrenocorticotropic hormone-producing sinusoidal neuroendocrine tumor associated with Cushing's disease. J. Vet. Med. Sci. 81(12): 1863-1867 (2019). 7. Kim HJ, Park JG, Moon KS, Jung SB, Kwon YM, Kang NS, Kim JH, Nam SJ, Choi G, Baek YB, Park SI. Identification and characterization of a marine bacterium extract from Mameliella sp. M20D2D8 with antiviral effects against influenza A and B viruses. Arch Virol. 169(3):41 (2024). Journal Country Publisher Impact factor* Ranking Signal Transduction and Targeted Therapy United Kingdom Springer Nature 39.3 3 / 285 (Biochemistry & Molecular Biology) Journal of Virology USA American Society for Microbiology 5.4 11 / 36 (Virology) European Journal of Pharmacology Netherlands Elsevier 5.0 60 / 277 (Pharmacology & Pharmacy) PLos One USA Public Library Science 3.7 26 / 73 (Multidisciplinary Sciences) *IF: Impact factor (2022) 연구업적(공저자논문) 1. Kim HJ, Cho KO, Baek YB. Foreign body reaction to ruptured follicular cysts in dogs. Vet. Med. Sci. 7(5): 1509-1513 (2021). 2. Kim CJ, Park SC, Lee SH, Lim YJ, Yoon M, Park JG, Baek YB, Cho KO, Hong JW, Shin DJ, Kim SK. Safety analysis of ex vivo-expanded canine natural killer cells in a xenogeneic mouse model of graft-versus-host disease. J. Leukoc. Biol. 111(2): 439-450 (2022). 3. Eom S, Kim C, Yeom HD, Lee J, Lee S, Baek YB, Na J, Park SI, Kim GY, Lee CM, Lee JH. Molecular Regulation of α3β4 Nicotinic Acetylcholine Receptors by Lupeol in Cardiovascular System. Int. J. Mol. Sci. 21(12): 4329 (2022). 4. Alfajaro MM, Kim JY, Barbé L, Cho EH, Park JG, Soliman M, Baek YB, Kang MI, Kim SH, Kim GJ, Park SI, Pendu JL, Cho KO. Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains. J. Virol. 93(18): e00941-19 (2019). 5. Yoon S, Lee SK, Lee J, Baek YB, Cho KO, Choi J.Dual Recognition of Sialic Acid and αGal Epitopes by the VP8* Domains of the Bovine Rotavirus G6P[5] WC3 and of Its Mono-reassortant G4P[5] RotaTeq Vaccine Strains. J. Vet. Med. Sci. 81(6): 928-932 (2019). 6. Park JG, Alfajaro MM, Cho EH, Kim JY, Soliman M, Baek YB, Park CH, Lee JH, Son KY, Cho KO, Kang MI. Development of a live attenuated trivalent porcine rotavirus A vaccine against disease caused by recent strains most prevalent in South Korea. Vet. Res. 50(1): 2 (2019). 7. Alfajaro MM, Cho EH, Kim DS, Kim JY, Park JG, Soliman M, Baek YB, Park CH, Kang MI, Park SI, Cho KO. Early Porcine Sapovirus Infection Disrupts Tight Junctions and Uses Occludin as a Corecepto. J. Virol. 93(4): e01773-18 (2019). 8. Soliman M, Kim DS, Park JG, Kim JY, Alfajaro MM, Baek YB, Cho EH, Park CH, Kang MI, Park SI, Cho KO. Early Porcine Sapovirus Infection Disrupts Tight Junctions and Uses Occludin as a Coreceptor. J. Virol. 81(6): 928-932 (2019). 9. Soliman M, Cho EH, Park JG, Kim JY, Alfajaro MM, Baek YB, Kim DS, Kang MI, Park SI, Cho KO. Rotavirus-Induced Early Activation of the RhoA/ROCK/MLC Signaling Pathway Mediates the Disruption of Tight Junctions in Polarized MDCK Cells. Sci. Rep. 8(1): 13931 (2018). 10. Soliman M, Kim DS, Kim C, Seo JY, Kim JY, Park JG, Alfajaro MM, Baek YB, Cho EH, Park SI, Kang MI, Chang KO, Goodfellow I, Cho KO. Porcine sapovirus Cowden strain enters LLC-PK cells via clathrin- and cholesterol-dependent endocytosis with the requirement of dynamin II. Sci. Rep. 8(1): 13931 (2018). 11. Alfajaro MM, Cho EH, Park JG, Kim JY, Soliman M, Baek YB, Kang MI, Park SI, Cho KO. Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects. PLoS One. 13(7): e0200726 (2018). 12. Cho EH, Soliman M, Alfajaro MM, Kim JY, Seo JY, Park JG, Kim DS, Baek YB, Kang MI, Park SI, Le Pendu J, Cho KO. Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens. J. Virol. 92(9): e02160-17 (2018). 13. Soliman M, Seo JY, Kim DS, Kim JY, Park JG, Alfajaro MM, Baek YB, Cho EH, Kwon J, Choi JS, Kang MI, Park SI, Cho KO. Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating. PLoS Pathog. 14(1): e1006820 (2018). 14. Kim JY, Kim DS, Seo JY, Park JG, Alfajaro MM, Soliman M, Baek YB, Cho EH, Kwon HJ, Park SJ, Kang MI, Cho KO. Glycan-specificity of four neuraminidase-sensitive animal rotavirus strains. Vet. Microbiol. 207: 159-163 (2017). 15. Alfajaro MM, Choi JS, Kim DS, Seo JY, Kim JY, Park JG, Soliman M, Baek YB, Cho EH, Kwon J, Kwon HJ, Park SJ, Lee WS, Kang MI, Hosmillo M, Goodfellow I, Cho KO. Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production. J. Virol. 91(3): e01656-16 (2017). 16. Bak GY, Kang MI, Son KY, Park JG, Kim DS, Seo JY, Kim JY, Alfajaro MM, Soliman M, Baek YB, Cho EH, Kwon J, Choi JS, Park SI, Cho KO. Occurrence and molecular characterization of Sapelovirus A in diarrhea and non-diarrhea feces of different age group pigs in one Korean pig farm. J. Vet. Med. Sci. 78(12): 1911-1914 (2017). 17. Kim DS, Kang MI, Son KY, Bak GY, Park JG, Hosmillo M, Seo JY, Kim JY, Alfajaro MM, Soliman M, Baek YB, Cho EH, Lee JH, Kwon J, Choi JS, Goodfellow I, Cho KO. Pathogenesis of Korean SapelovirusA in piglets and chicks. J. Gen. Virol. 97(10): 2566-2574 (2016). 18. Park JG, Park SI, Woo NI, Kim DS, Seo JY, Alfajaro MM, Kim JY, Soliman M, Baek YB, Cho EH, Kwon J, Choi JS, Kang MI, Matthijnssens J, Cho KO. Whole genomic characterization of Korean porcine G8P[7] reassortant rotaviruses. Arch. Virol. 161(10): 2835-41 (2016). 19. Kim DS, Son KY, Koo KM, Kim JY, Alfajaro MM, Park JG, Hosmillo M, Soliman M, Baek YB, Cho EH, Lee JH, Kang MI, Goodfellow I, Cho KO. Porcine Sapelovirus Uses α2,3-Linked Sialic Acid on GD1a Ganglioside as a Receptor. J. Virol. 90(8): 4067-4077 (2016). 20. Jeong YJ, Matthijnssens J, Kim DS, Kim JY, Alfajaro MM, Park JG, Hosmillo M, Son KY, Soliman M, Baek YB, Kwon J, Choi JS, Kang MI, Cho KO. Genetic diversity of the VP7, VP4 and VP6 genes of Korean porcine group C rotaviruses. Vet. Microbiol. 176(1-2): 61-9 (2015). 연구업적(특허) 2017 - 2017 Pharmaceutical composition for preventing or treating Calicivirus infection. Application number: 1020160065784 Registration number: 1018053940000 2018 - 2019 Mixed live attenuated vaccine composition for protecting porcine rotavirus infection Application number: 1020180030498 Registration number: 1020896550000 2018 - 2019 Mixed live attenuated vaccine composition for protecting bovine rotavirus infection Application number: 1020180030499 Registration number: 1020383640000 2018 - 2020 A live attenuated vaccine composition of KWD20V-102 strain for protecting bovine coronavirus infection Application number: 1020180096348 Registration number: 1020896550000 2021 - 2023 Hepcidin-derived mutant peptide for treating and preventing cytokine release syndrome, the composition comprising the same. Registration number: 1025803770000 2022 - present Pharmaceutical composition containing lipolytic enzyme inhibitors for preventing or treating RNA virus infection Application number: 1020220077063 2022 - present Pharmaceutical composition containing lipolytic enzyme inhibitors for preventing or treating RNA virus infection Application number: PCT/KR2022/009041 Technology Transfer 2023. 12. Development of Anti-inflammatory Pet Food Using Aster glehni and Natural Product Principal Investigator